“Earlier this month, a team from UC Berkeley took a stab at taming the CRISPR beast. Using a technique called circular permutation, the team reorganized CRISPR into a programmable tool dubbed ProCas9 that silently lurks within cells until external factors—viral infection, for example—wakes it up.

It’s an “extra layer of security” that limits CRISPR’s editing skills to only a subset of cells “to ensure accurate cutting,” said study author Dr. David Savage…”

Source: https://singularityhub.com/2019/01/23/crispr-just-got-more-powerful-with-an-on-switch/